ABAMAV® Components

ABAMAV® COMPONENTS Confidential: DETAILED INFORMATION ON REQUEST ONLY

 

 

AlgaeAlgae [689 Kb]

ABAMAV® COMPONENTS Confidential: DETAILED INFORMATION ON REQUEST ONLY

 

Ocean-Sea algae are the richest natural source of minerals, trace minerals and rare earth elements.

Ref. Handbook of Chemistry and Physics, 65th Ed. 1984-1985, CRC Press, Boca Raton, Fl., p. F-149

 

 

Aluminum AL       Molybdenum MO
Antimony SB        Neodymium ND
Arsenic AS           Nickel NI
Barium BA           Niobium NB
Beryllium BE        Osmium OS
Bismuth BI          Palladium PD
Boron B               Phosphorus P
Bromine BR         Platinum PT
Cadmium CD       Potassium K
Calcium CA          Praseodymium PR
Carbon C             Rhenium RE
Cerium CE           Rhodium RH
Cesium CS           Rubidium RB
Chloride CL          Ruthenium RU
Chromium CR       Samarium SM
Cobalt CO            Scandium SC
Copper CU           Selenium SE
Dysprosium DY     Silicon SI
Erbium ER            Silver AG
Europium EU         Sodium NA
Fluoride F             Strontium SR
Gadolinium GD      Sulfur (sulfate) S
Gallium GA           Tantalum TA
Germanium GE      Tellurium TE
Gold AU               Terbium TB
Hafnium HF           Thallium TL
Holmium HO         Thorium TH
Indium IN             Thulium TM
Iodine I                Tin SN
Iridium IR             Titanium TI
Iron FE                 Tungsten W
Lanthanum LA       Vanadium V
Lead PB                Ytterbium YB
Lithium LI             Yttrium Y
Lutetium LU           Zinc ZN
Magnesium MG      Zirconium ZR
Manganese MN
Mercury HG

 

Minerals that are negatively charged have two very important benefits.

It greatly increases the transport and bioavailability of other nutrients gotten from foods and/or vitamins and other supplements.

It will attract toxins and heavy metals from the body and flush them out.

Clinical tests done in the US. and in Germany have verified this.

Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis

PubMed - 9593452 
http://www.ncbi.nlm.nih.gov/pubmed/9593452 

 Harvard Medical School, Boston, Massachusetts 02115, USA. and ...Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute


Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis (Arthrospira platensis). 73J Acquir Immune Defic Syndr Hum Retrovirol. 1998 May 1;18(1):7-12. Ayehunie S, Belay A, Baba TW, Ruprecht RM. 

An aqueous extract of the blue-green filamentous algae Arthrospira platensis (previously called Spirulina platensis) inhibited HIV-1 replication in human T- cell lines, peripheral blood mononuclear cells (PBMC), and Langerhans cells (LC). Extract concentrations ranging between 0.3 and 1.2 microg/ml reduced viral production by approximately 50% (50% effective concentration [EC50]) in PBMCs. The 50% inhibitory concentration (IC50) of extract for PBMC growth ranged between 0.8 and 3.1 mg/ml. Depending on the cell type used, therapeutic indices ranged between 200 and 6000. The extract inactivated HIV-1 infectivity directly when preincubated with virus before addition to human T-cell lines. Fractionation of the extract revealed antiviral activity in the polysaccharide fraction and also in a fraction depleted of polysaccharides and tannins. We conclude that aqueous A platensis extracts contain antiretroviral activity that may be of potential clinical interest

Publication Types:U.S. Gov't PMID: 9593452 [PubMed - indexed for MEDLINE]
 

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A natural sulfated polysaccharide, calcium spirulan, isolated from Spirulina platensis: in vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities. AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1463-71. 

Hayashi K, Hayashi T, Kojima I. Department of Virology, Toyama Medical and Pharmaceutical University, Japan. 

A sulfated polysaccharide named calcium spirulan (Ca-SP) has been isolated from a sea alga, Spirulina platensis, as an antiviral component. The anti-human immunodeficiency virus type 1 (HIV-1) and anti-herpes simplex virus type 1 (HSV-1) activities of Ca-SP were compared with those of dextran sulfate (DS) as a representative sulfated polysaccharide. Anti-HIV-1 activities of these agents were measured by three different assays: viability of acutely infected CD4- positive cells, or a cytopathology assay; determination of HIV-1 p24 antigen released into culture supernatants; and inhibition of HIV-induced syncytium formation. Anti-HSV-1 activity was assessed by plaque yield reduction. 

In addition, their effects on the blood coagulation processes and stability in the blood were evaluated. These data indicate that Ca-SP is a potent antiviral agent against both HIV-1 and HSV-1. Furthermore, Ca-SP is quite promising as an anti-HIV agent because even at low concentrations of Ca-SP an enhancement of virus- induced syncytium formation was not observed, as was observed in DS-treated cultures, Ca-SP had very low anticoagulant activity, and showed a much longer half-life in the blood of mice when compared with that of DS. Thus, Ca-SP can be a candidate agent for an anti-HIV therapeutic drug that might overcome the disadvantages observed in many sulfated polysaccharides. When the role of chelation of calcium ion with sulfate groups was examined by removing calcium or its replacement by sodium, the presence of calcium ion in the molecule was shown to be essential for the dose-dependent inhibition of cytopathic effect and syncytium formation induced by HIV-1.
PMID: 8893054 [PubMed - indexed for MEDLINE]

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Spirulina in Clinical Practice: Evidence-Based Human Applications. Karkos PD, Leong SC, Karkos CD, Sivaji N, Assimakopoulos DA. Source Specialist Registrar in Otolaryngology, 36 Hopkinsons Court, Walls Avenue, Chester CH1 4LN, UK. E- pkarkos@aol.com. Abstract Spirulina or Arthrospira is a blue-green alga that became famous after it was successfully used by NASA as a dietary supplement for astronauts on space missions. It has the ability to modulate immune functions and exhibits anti-inflammatory properties by inhibiting the release of histamine by mast cells. Multiple studies investigating the efficacy and the potential clinical applications of Spirulina in treating several diseases have been performed and a few randomized controlled trials and systematic reviews suggest that this alga may improve several symptoms and may even have an anticancer, antiviral and antiallergic effects. Current and potential clinical applications, issues of safety, indications, side-effects and levels of evidence are addressed in this review. Areas of ongoing and future research are also discussed. PubMed: 18955364 - PMCID: PMC3136577 

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Antiviral activity of Arthrospira-derived spirulan-like substances. Rechter S, König T, Auerochs S, Thulke S, Walter H, Dörnenburg H, Walter C, Marschall M. Source Institute for Clinical and Molecular Virology, University of Erlangen-Nürnberg, Germany. Abstract Natural substances offer interesting pharmacological perspectives for antiviral drug development in regard to broad-spectrum antiviral properties and novel modes of action. In this study we analyzed polysaccharide fractions isolated from Arthrospira platensis. Fractions containing intracellular or extracellular spirulan-like molecules showed a pronounced antiviral activity in the absence of cytotoxic effects. Using specific assays for the quantification of viral replication in vitro, these substances exhibited strong inhibition of human cytomegalovirus, herpes simplex virus type 1, human herpesvirus type 6 and human immunodeficiency virus type 1, while only weak or no inhibition was noted for Epstein-Barr virus and influenza A virus. Considering herpesviruses, antiviral effects were most pronounced when the cells were preincubated with the substances prior to the addition of virus, indicating that antiviral action may be primarily targeted to virus entry. However, an inspection of the inhibition of human cytomegalovirus protein synthesis clearly demonstrated that intracellular steps also contributed to the antiviral effect. In the case of human immunodeficiency virus, inhibition occurred at a stage later than viral entry. Thus, spirulan-like substances possess a marked antiherpesviral and anti-HIVactivity based on different modes of action. Further development of these substances might yield novel candidates of broad-spectrum antiviral drugs. PubMed 16884788 

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Structural Analysis of Calcium Spirulan (Ca−SP)-Derived Oligosaccharides Using Electrospray Ionization Mass Spectrometry AbstractFull Text HTMLHi-Res PDF[50 KB]PDF w/ Links[101 KB]FiguresCiting Articles Your current credentials do not allow retrieval of the full text. Purchase the full-text Jung-Bum Lee,Toshimitsu Hayashi,* Kyoko Hayashi, and Ushio Sankawa Faculty of Pharmaceutical Sciences and School of Medicine, Toyama Medical & Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan J. Nat. Prod., 2000, 63 (1), pp 136 - 138 DOI: 10.1021/np990348b Publication Date (Web): November 19, 1999 Copyright 2000 American Chemical Society and American Society of Pharmacognosy Section:Carbohydrates Abstract Detailed structural analyses of calcium spirulan (Ca−SP)-derived oligosaccharides were performed by ESI-MS and collision-induced dissociation tandem mass spectrometry. This study indicates that Ca−SP is composed of two types of disaccharide repeating units, O-rhamnosyl-acofriose and O-hexuronosyl-rhamnose (aldobiuronic acid). 

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Effects on the AIDS Virus, Cancer and the Immune System. by Richard Kozlenko DPM, Ph.D M.P.H. and Ronald H. Henson. Copyright 1998 
Spirulina is gaining more attention from medical scientists as a nutraceutical and source of potential pharmaceuticals. There are several new peer reviewed scientific studies about Spirulina's ability to inhibit viral replication, strengthen both the cellular and humoral arms of the immune system and cause regression and inhibition of cancers. While these studies are preliminary and more research is needed, the results so far are exciting.

Potent Anti-Viral Activity
In April 1996, scientists from the Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, and Earthrise Farms, Calipatria, California, announced on-going research, saying "Water extract of Spirulina platensis inhibits HIV-1 replication in human derived T-cell lines and in human peripheral blood mononuclear cells. A concentration of 5-10 mcg/ml was found to reduce viral production" 1.

HIV-1 is the AIDS virus. Small amounts of Spirulina extract reduced viral replication while higher concentrations totally stopped its reproduction. Importantly, with a therapeutic index of >100, Spirulina extract was non-toxic to the human cells at concentrations stopping viral replication.

Another group of medical scientists has published new studies regarding a purified water extract unique to Spirulina named Calcium-Spirulan. It inhibits replication of HIV-1, Herpes Simplex, Human Cytomegalovirus, Influenza A virus, Mumps virus and Measles virus in-vitro yet is very safe for human cells. It protects human and monkey cells from viral infection in cell culture. According to peer reviewed scientific journal reports this extract, "holds great promise for treatment of ...HIV-1, HSV-1, and HCM infections, which is particularly advantageous for AIDS patients who are prone to these life-threatening infections." 8.

Calcium-Spirulan is a polymerized sugar molecule unique to Spirulina containing both Sulfur and Calcium. Hamsters treated with this water soluble extract had better recovery rates when infected with an otherwise lethal Herpes virus 9. 
How does it work? When attacking a cell, a virus first attaches itself to the cell membrane. However, because of Spirulina extract, the virus cannot penetrate the cell membrane to infect the cell. The virus is stuck, unable to replicate. It is eventually eliminated by the body's natural defenses. Spirulina extracts may become useful therapeutics that could help AIDS patients lead longer more normal lives 1, 8, 9. 

What Is Spirulina?
Spirulina, (rhymes with 'ballerina'), is a traditional food of some Mexican and African peoples. It is a planktonic blue-green algae found in warm water alkaline volcanic lakes. Wild Spirulina sustains huge flocks of flamingos in the alkaline East African Rift Valley Lakes. It possesses an amazing ability to thrive in conditions much too harsh for other algae. As might be expected, it has a highly unusual nutritional profile. Spirulina has a 62% amino acid content, is the world's richest natural source of Vitamin B-12 and contains a whole spectrum of natural mixed carotene and xanthophyll phytopigments. Spirulina has a soft cell wall made of complex sugars and protein, and is different from most other algae in that it is easily digested.

Millions of people worldwide eat Spirulina cultivated in scientifically designed algaefarms. Current world production of Spirulina for human consumption is more than one thousand metric tons annually. The United States leads world production followed by Thailand, India and China. More countries are planning production as they realize it is a valuable strategic resource.

Differences between spirulina, chlorella and 'wild' blue green algae.

Spirulina is not Chlorella or the blue-green algae harvested from Klamath Lake Oregon. Chlorella, a green micro-algae, is a nutritious food but does not have the same anti-viral, anti-cancer and immune stimulating properties of Spirulina. The Chlorella cell wall is made of indigestible cellulose, just like green grass, while the cell wall of Spirulina is made of complexed proteins and sugars. 

The Klamath Lake blue-green algae has the scientific name Aphanizomenon flos-aquae. It is not the same as Spirulina. There are serious concerns about the safety of eating Aphanizomenon flos-aquae 5, because it can sometimes contain potent nerve toxins. While the scientific literature is full of information concerning the toxicity of Aphanizomenon flos-aquae and its dangers to humans and animals, there are few, if any, peer reviewed scholarly scientific papers regarding therapeutic benefit. In contrast, the scientific literature is full of information concerning the benefits and safety of humans and animals eating Chlorella and Spirulina 4.

Anti-Cancer Effects Several studies show Spirulina or its extracts can prevent or inhibit cancers in humans and animals. Some common forms of cancer are thought to be a result of damaged cell DNA running amok, causing uncontrolled cell growth. Cellular biologists have defined a system of special enzymes called Endonuclease which repair damaged DNA to keep cells alive and healthy. When these enzymes are deactivated by radiation or toxins, errors in DNA go unrepaired and, cancer may develop. In vitro studies suggest the unique polysaccharides of Spirulina enhance cell nucleus enzyme activity and DNA repair synthesis. This may be why several scientific studies, observing human tobacco users and experimental cancers in animals, report high levels of suppression of several important types of cancer. The subjects were fed either whole Spirulina or treated with its water extracts 3,12,13.

Strengthens Immune System
Spirulina is a powerful tonic for the immune system. In scientific studies of mice, hamsters, chickens, turkeys, cats and fish, Spirulina consistently improves immune system function. Medical scientists find Spirulina not only stimulates the immune system, it actually enhances the body's ability to generate new blood cells.

Important parts of the immune system, the Bone Marrow Stem Cells, Macrophages, T-cells and Natural Killer cells, exhibit enhanced activity. The Spleen and Thymus glands show enhanced function. Scientists also observe Spirulina causing macrophages to increase in number, become "activated" and more effective at killing germs.

Feeding studies show that even small amounts of Spirulina build up both the humoral and cellular arms of the immune system 16. Spirulina accelerates production of the humoral system, (antibodies and cytokines), allowing it to better protect against invading germs. The cellular immune system includes T-cells, Macrophages, B-cells and the anti-cancer Natural Killer cells. These cells circulate in the blood and are especially rich in body organs like the liver, spleen, thymus, lymph nodes, adenoids, tonsils and bone marrow. Spirulina up-regulates these key cells and organs, improving their ability to function in spite of stresses from environmental toxins and infectious agents 2,10,12,14,15,16. 

Spirulina Phycocyanin Builds Blood
Spirulina has a dark blue-green color, because it is rich in a brilliant blue polypeptide called Phycocyanin. Studies show that Phycocyanin affects the stem cells found in bone marrow. Stem cells are "Grandmother" to both the white blood cells that make up the cellular immune system and red blood cells that oxygenate the body. Chinese scientists document Phycocyanin stimulating hematopoiesis, (the creation of blood), emulating the affect of the hormone erythropoetin, (EPO). EPO is produced by healthy kidneys and regulates bone marrow stem cell production of red blood cells. Chinese scientists claim Phycocyanin also regulates production of white blood cells, even when bone marrow stem cells are damaged by toxic chemicals or radiation 17. 

Based on this effect, Spirulina is approved in Russia as a "medicine food" for treating radiation sickness. The Children of Chernobyl suffer radiation poisoning from eating food grown on radioactive soil. Their bone marrow is damaged, rendering them immunodeficient. Radiation damaged bone marrow cannot produce normal red or white blood cells. The children are anemic and suffer from terrible allergic reactions. Children fed just five grams of Spirulina in tablets each day make dramatic recoveries within six weeks. Children not given Spirulina remain ill 6.

Other Potential Health Benefits
Spirulina is one of the most concentrated natural sources of nutrition known. It contains all the essential amino acids, rich in chlorophyll, beta-carotene and its co-factors, and other natural phytochemicals. Spirulina is the only green food rich in GLA essential fatty acid. GLA stimulates growth in some animals and makes skin and hair shiny and soft yet more durable. GLA also acts as an anti-inflammatory, sometimes alleviating symptoms of arthritic conditions.

Spirulina acts as a functional food, feeding beneficial intestinal flora, especially Lactobacillus and Bifidus. Maintaining a healthy population of these bacteria in the intestine reduces potential problems from opportunistic pathogens like E. coli and Candida albicans. Studies show when Spirulina is added to the diet, beneficial intestinal flora increase.

Conclusion
Based on this preliminary research, scientists hope the use of Spirulina and its extracts may reduce or prevent cancers and viral diseases. Bacterial or parasitic infections may be prevented or respond better to treatment and wound healing may improve. Symptoms of anemia, poisoning and immunodeficiency may be alleviated. Scientists in the USA, Japan, China, Russia, India and other countries are studying this remarkable food to unlock its potential. More research is needed to determine its usefulness against AIDS and other killer diseases. However, it is already clear this safe and natural food provides concentrated nutritional support for optimum health and wellness.