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Anti-malarial and anti-tuberculosis activities from a brown alga Dictyota sp.

J. Jongaramruonga* & N. Kongkama pages 743-751

Abstract
Two new diterpenes, (1E,2R*,3R*,4S*,6E,18S*)-4,18-dihydroxydictyolactone (1) and 8α,11-dihydroxypachydictyol A (2), together with fucoxanthin (3) and a known diterpene 4α-hydroxycrenulatane (4) were isolated from the methanol extract of the brown alga Dictyota sp. collected from Bangsaen Beach, Thailand.

Their structures were determined by spectroscopic data.

The relative stereochemistry of 1 was established by NOE difference and NOESY experiments.

Compound 1 showed weak anti-tuberculosis activity while 2 displayed strong cytotoxicity against the NCI-H187 cell line, and potent anti-malarial activity. In addition, 3 was active against HSV-1 and malarial parasites.

Marine Compounds with ... Antifungal, Anti-inflammatory, Antimalarial...

Marine pharmacology in 2005–6: Marine Compounds with Anthelmintic, Antibacterial, Anticoagulant, Antifungal, Anti-inflammatory, Antimalarial, Antiprotozoal, Antituberculosis, and Antiviral Activities; affecting the Cardiovascular, Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action Alejandro M. S. Mayer,1 Abimael D. Rodriguez,2 Roberto G. S. Berlinck,3 and Mark T. Hamann4 1 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern, University, 555 31st Street, Downers Grove, Illinois 60515, U.S.A 2 Department of Chemistry, University of Puerto Rico, San Juan, Puerto Rico 00931, U.S.A 3 Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, Brazil 4 School of Pharmacy, Chemistry & Biochemistry, The University of Mississippi, Faser Hall, University, Mississippi 38677, U.S.A Author to whom correspondence should be addressed: Alejandro M.S. Mayer, Ph.D., Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735450/

Artemisia roxburghiana and Plasmodium falciparum

National Institute of Malaria Research, Field Unit, Hardwar 249403, India.
PMID: 21527328 [PubMed - indexed for MEDLINE]

Fiji red sea ALGAE could treat Malaria

WASHINGTON D.C. - The University of the South Pacific Institute of Applied Science is happy with the break-through as it has hoped for years to help develop an anti-malaria drug.

Chemicals In The Algae Helps To Protect Against Malaria

Antifungal Compounds from Seaweed Show Antimalarial Potential